2024 CSBC / MetNet Annual Investigators Meeting

Tech Check for Day 1 Speakers

Coffee service provided. 

• Welcome - Nevan Krogan, University of California - San Francisco
• About the Meeting - Andrew Gentles, Stanford University
• Welcoming Remarks - Dan Gallahan, Director, Division of Cancer Biology, NCI

Session Chairs: Stacey Finley, USC; David DeNardo, Washington University of St. Louis

9:30 - 9:45 AM    From Nerves to Nodules: How Sensory Nerves Fuel Breast Cancer - Veena Padmanaban, Rockefeller University (MetNet)

9:45 AM    Investigating disseminated cancer cell clonal cooperation and immune control in dormancy and metastasis - Carolina Rodriguez-Tirado, Albert Einstein College of Medicine  (MetNet)

9:50 AM    Agent-based Modeling of Dysregulated Cell Signaling and the Tumor-Immune Landscape Predicts New Possibilities for Combination Therapy - Trachette Jackson, University of Michigan (CSBC)

9:55 AM    Spatial transcriptomics of patient-matched primary and LN metastases maps phenotypic evolution - Katherine Ventre, New York University (MetNet)

10:00 - 10:15AM    The ST-Analytics U54 program: Towards Understanding the Benefits of Sequencing Cancer Immunotherapy with Targeted Inhibitors for Tumor Eradication - Jim Heath, Institute for Systems Biology (CSBC)

10:15 AM    Tumor hybrid cells in metastasis - Chia-Nung Hung, UT Health San Antonio (MetNet)

10:20 AM    Plasma exosomes from individuals with type 2 diabetes drive breast cancer progression in patient-derived organoids - Christina Ennis, Boston University (CSBC)

10:25 - 10:40AM    Molecular Networks and Intelligent Systems for Precision Oncology -  Nevan Krogan, UCSF (CSBC)

Attach your posters

Session Chairs: Ivy Xiong, UCLA; Markus Schober, NYU Langone

10:55 - 11:10 AM    Multiomic and spatial dissection of the tumor immune microenvironment - Xiao Huang, Memorial Sloan Kettering (CSBC)

11:10 AM    Dissecting subpopulation responses to therapy in triple negative breast cancer models - Amy Brock, University of Texas at Austin (CSBC)

11:15 AM    RGI-I-dependent type I interferon mediates tumor-intrinsic inflammation in breast cancer 3D culture - Kat Liu, Stanford University (MetNet)

11:20 AM    Mechanistic maps of adaptive responses to therapeutic stress to optimize combination therapies - Anil Korkut, UT MDACC (CSBC)

11:25 - 11:40    Spatial niche reprogramming and genomic instability in colorectal cancer brain metastasis - Anuja Sathe, Stanford University (MetNet) 

11:40 AM    Mapping the Medulloblastoma Landscape and a Path to Better Therapies - Veronika Pister, MIT (CSBC)

11:45 AM    Assessment of E-cadherin dynamics and metastatic trajectories in a mouse model of luminal breast cancer - Ryan Huizar, Johns Hopkins University  (MetNet)

11:50 - 12:05 PM    Systems modeling of a mitotic organelle in triple-negative breast cancer - Kevin Janes, University of Virginia  (CSBC)

Lunch provided by the MC2 Center / Sage Bionetworks   

Attach your posters if you have not already

Session Chairs: Mohammed Fallahi-Sichani, University of Virginia; Veedma Padmanaban, Rockefeller University

1:45 - 2:00 PM    Complex rearrangements fuel the progression of High-risk Er-positive and HER2-positive breast tumors - Lise Mangiante, Stanford University, (MetNet) 

2:00 PM    Exploring the epigenetic landscape and metastatic potential of MDA-MB21 tumor cells grown on different substrate stiffness in 2D and 3D environments - Nicolas Acosta, Northwestern University (MetNet)

2:05 PM    Overcoming Intrinsic Mechanisms of Cell Cycle Inhibitor Resistance in Estrogen Receptor-Positive (ER+) Breast Cancer - Aritro Nath, City of Hope (CSBC)

2:10 PM    Organ-specific macrophages may lead to suppressive tumor microenvironment in metastatic pancreatic cancer - Yu-Lan Kao, Washington University in St. Louis (MetNet)

2:15 - 2:30 PM  The Delta Ecology of Non-Small Cell Lung Cancer -Sandy (Alexander) Anderson, Moffitt Cancer Center (CSBC)

2:30 PM    Modeling Genetic Subclones and Transcriptional Programs in IPMN Progression to High-Grade Dysplasia -  Rachel Karchin, Johns Hopkins University (CSBC)

2:35 PM    Transcriptomic analysis of cell-free RNA extracted from the cerebrospinal fluid of patients with brain metastases -Guiseppe Barisano, Stanford University (MetNet)

2:40 - 2:55 PM   Identifying and exploiting mechano-chemical vulnerabilities during metastatic organ colonization - Peter Friedl, Radboudumc (MetNet)

2:55 - 3:10 PM    MIT/DFCI Center for Glioblastoma Systems Biology - Forest White, MIT (CSBC)

Session Chairs: Eva Hernando, NYU School of Medicine; Forest White, MIT

3:10 - 3:40 PM Experimental Methods and Computational Pipelines for Spatial ATAC-se Profiling of Tumor Tissues - Chong Xia and Juho Kim, Institute for Systems Biology (20 min talk + 10 min QA)

3:45 - 4:15 PM Metastatic knowledge: transfer learning of gene regulatory signatures - Genevieve Stein-O'Brien, Josh Hopkins University (20 min talk + 10 min QA)

Hors d'oeuvres and nonalcoholic drinks provided by MC2 Center / Sage Bionetworks. 

Tech Check for Day 1 Speakers

Coffee service provided. 

Introduced by: Andrew Ewald, Johns Hopkins Medicine

Session Chairs: Aritro Nath, City of Hope; Ana Calizo, Johns Hopkins University

9:30 - 9:45 AM    Mathematical Oncology Systems Analysis of Imaging Center- Kristin Swanson, Mayo Clinic (CSBC)

9:45 AM    Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A- Gregory Donaldson, Rockefeller University (MetNet)

9:50 AM    Decoding the cellular and spatial complexity of lung cancer development - Humam Kadara and Linghua Wang, University of Texas MD Anderson Center (CSBC)

9:55 - 10:10 AM    Identifying regulators of intratumor heterogeneity in early-stage melanoma - Paola Angulo-Salgado and Markus Schober (MetNet)

10:10 - 10:25 AM    The Cancer Systems Therapeutics Center (CaST) at Columbia University - Andrea Califano,  Columbia University (CSBC)

10:25 AM    Systems analysis of mechanisms driving response to immunotherapy in clear cell cancers - Andrew Gentles, Stanford University (CSBC)

10:30 AM    Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization in cancer cells -Monika Dhankar, University of Pennsylvania (MetNet)

10:35 AM    Spotiphy enables single-cell spatial whole transcriptomics across the entire section - Jiyang Yu, St. Jude Children’s Research Hospital (CSBC)

10:40 - 11:05 PM    Stanford Center for Cancer System Biology: Systems Biology of Tumor Immune Stromal Interactions in Metastatic Progression - Sylvia Plevritis, Stanford University (CSBC)

Led by Jineta Banerjee and Orion Banks, MC2 Center / Sage Bionetworks

Lunch provided by the MC2 Center / Sage Bionetworks   

"Meet the Experts" - Lunch Round Table Discussion

Session Chairs: Sepideh Dolatshahi, University of Virginia; Peter Friedl, Radboud University Medical Center

Panelists: Sandy Anderson, Moffitt Cancer Center; Andrea Califano, Columbia University; Melanie Hayden-Gephart, Stanford; Vivian Lee, Patient Advocate, Stanford; Vivek Shenoy, University of Pennsylvania

45 minute panel

45 minute group discussion / Q&A

Session Chair: Maxine Umeh-Garcia, Stanford University

Panelists: Dan Gallahan, Division of Cancer Biology, NCI; Susie Brain, Stanford University; Stacey Finley, University of Southern California; Forest White, MIT

Hors d'oeuvres and nonalcoholic drinks provided by MC2 Center / Sage Bionetworks.     

All posters must be removed at the end of this session - poster board pick up will take place immediately following this session.

Harmonic Brewing Thrive City

7 Warriors Way Ste 206

Food and nonalcoholic drinks provided by MC2 Center / Sage Bionetworks.

Session Chairs: Sohail Tavazoie, Rockefeller University; Linghua Wang, MD Anderson

Panelists: Daniel Mucida, The Rockefeller University; Trey Ideker, University of California - San Diego; Christina Curtis, Stanford University; and Sylvia Plevritis, Stanford University; Deena Oren, The Rockefeller University

45 minute panel

45 minute group discussion / Q&A

• People's Choice Poster Award - MetNet Patient Advocate Working Group
• Best Scientific Poster Award - Rosela Golloshi, Johns Hopkins University
• Closing Remarks - Joanna Watson, Chief of Tumor Metastasis Branch, Division of Cancer Biology, NCI